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Ketamine is a white, crystalline powder or clear liquid. Buy high-quality Ketamine Crystal Powder for sale online without a prescription. Discover the powerful effects of this white, crystalline powder.

Synonyms of Ketamine Crystal Powder

(+/-)-2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone; Ketalar®, Ketaject®, Ketaset®, Vetalar®; K, Special K, Vitamin K, Lady K, Jet, Super Acid, Bump, Special LA Coke, KitKat, Cat Valium. Buy Ketamine Crystal Powder for Sale Online Without Prescription.

Source of Ketamine Crystal Powder

Available by prescription only, and is commercially available as a veterinary anesthetic. It is difficult to synthesize clandestinely and is usually stolen from veterinarian offices or divert from legitimate pharmaceutical sources in liquid form. Ketamine is currently a schedule III controlled substance in the US.

Drug Class

Dissociative anesthetic, hallucinogen, psychotomimetic.

Medical and Recreational Uses of Ketamine Crystal Powder

Primarily used in veterinary applications as a tranquilizer. Also use as an anesthetic induction agent for diagnostic and surgical procedures in humans, prior to the administration of general anesthetics. Occasionally use as a short-acting general anesthetic for children and elderly patients. Recreationally used as a psychedelic and for its dissociative effects.

Potency, Purity and Dose

Ketamine is available as a racemic mixture with the S-(+)- isomer being more potent than the R-(-)- isomer. Commercially supplied as the hydrochloride salt in 0.5 mg/mL and 5 mg/mL ketamine base equivalents. For induction of 5-10 minutes surgical anesthesia, a dose of 1.0-4.5 mg/kg is intravenously administer; 6.5-13 mg/kg is given intramuscularly for 12-25 minutes of surgical anesthesia. The liquid from injectable solutions can be gently heat to evaporate the water, leaving a white powder (ketamine hydrochloride) which can be snort or orally ingest. Recreational doses are highly variable. Common doses are 25-50 mg intramuscularly, 30-75 mg snorting, and 75-300 mg oral. Snorting a small line (“bump”, 30-50 mg) usually results in a dreamy effect. “K-hole” can be obtain following a dose of 60-125 mg intramuscularly, or by snorting 100-250 mg. Impurities are rarely seen, although ketamine hydrochloride itself can be use as a heroin adulterant. Buy Ketamine Crystal Powder for Sale Online Without Prescription.

Route of Administration

Injected, snorted, orally ingested, and rectally administered. Similar to phencyclidine (PCP), ketamine can be add to tobacco or marijuana cigarettes and smoked.

Pharmacodynamics

Involves analgesia, anesthetic and sympathomimetic effects that are mediated by different sites of action. Non-competitive NMDA receptor antagonism is associated with the analgesic effects; opiate receptors may contribute to analgesia and dysphoric reactions; and sympathomimetic properties may result from enhanced central and peripheral monoaminergic transmission. Ketamine blocks dopamine uptake and therefore elevates synaptic dopamine levels. Inhibition of central and peripheral cholinergic transmission could contribute to induction of the anesthetic state and hallucinations. Ketamine is structurally similar to PCP, but 10-50 times less potent in blocking NMDA effects.

Pharmacokinetics

Bioavailability following an intramuscular dose is 93%, intranasal dose 25-50%, and oral dose 20±7%. Ketamine is rapidly distributed into brain and other highly perfused tissues, and is 12% bound in plasma. The plasma half-life is

2.3 ± 0.5 hours. Oral administration produces lower peak concentrations of ketamine, but increased amounts of the metabolites norketamine and dehydronorketamine. Ketamine and its metabolites undergo hydroxylation and conjugation. Norketamine produces effects similar to those of ketamine. There are no significant differences between the pharmacokinetic properties of the S-(+) and R-(-)-isomers.

Molecular Interaction / Receptor Chemistry

Cytochrome P450 3A4 is the principal enzyme responsible for ketamine N-demethylation to norketamine, with minor contributions from CYP2B6 and CYP2C9 isoforms . Potential inhibitors of these isoenzymes could decrease the rate of ketamine elimination if administered concurrently, while potential inducers could increase the rate of elimination.

Interpretation of Blood Concentrations

There is no direct correlation between ketamine concentrations and behavior. Drowsiness, perceptual distortions and intoxication may be dose relate in a concentration range of 50 to 200 ng/mL, and analgesia begins at plasma concentrations of about 100 ng/mL. During anesthesia, blood ketamine concentrations of 2000-3000 ng/mL are use, and patients may begin to awake from a surgical procedure when concentrations have been naturally reduce to 500-1000 ng/mL.

Interpretation of Urine Test Results

Urinary excretion of unchanged drug is 4±3%, and ketamine use can be detect in urine for about 3 days. Concentration ranges for ketamine in urine have been reported as low as 10 ng/mL and up to 25,000 ng/mL.

Effects of Ketamine Crystal Powder

Users have likened the physical effects of ketamine to those of PCP, and the visual effects to LSD.

Psychological

Decreased awareness of general environment, sedation, dream-like state, vivid dreams, feelings of invulnerability, increase distractibility, disorientation, and subjects are generally uncommunicative. Intense hallucinations, impaired thought processes, out-of-body experiences, and changes in perception about body, surroundings, time and sounds. Delirium and hallucinations can be experience after awakening from anesthesia.

Physiological: Anesthesia, cataplexy, immobility, tachycardia, increase blood pressure, nystagmus, hypersalivation, increase urinary output, profound insensitivity to pain, amnesia, slurred speech, and lack of coordination.

Side Effect Profile

High incidence of adverse effects, including anxiety, chest pain, palpitations, agitation, rhabdomyolysis, flashbacks, delirium, dystonia, psychosis, schizophenic-like symptoms, dizziness, vomiting, seizures, and paranoia.

Duration of Effects

Onset of effects is within seconds if smoked, 1-5 minutes if inject, 5-10 minutes if snorted and 15-20 minutes if orally administer. Effects generally last 30-45 minutes if injected, 45-60 minutes if snorted, and 1-2 hours following oral ingestion. Ketamine is often read minister due to its relatively short duration of action. Some subjects may experience dreams 24 hours later. Mark dissociative effects, schizotypal symptoms and impaired semantic memory are found in some recreational users days after drug use. Buy Ketamine Crystal Powder for Sale Online Without Prescription.

Tolerance, Dependence and Withdrawal Effects

In long-term exposure, high tolerance, drug craving, and flashbacks are describe. Little evidence of a physiological withdrawal syndrome unless abrupt discontinuation in chronic users.

Drug Interactions

Midazolam attenuates alter perception and thought processes. Lorazepam may decrease ketamine-associate emotional distress but does not decrease cognitive or behavioral effects of ketamine. Acute administration of diazepam increases the half-life of ketamine. Lamotrigine significantly decreases ketamine-induce perceptual abnormalities, but increases the mood elevating effects. Haloperidol may decrease impairment by ketamine in executive control functions, but does not affect psychosis, perceptual changes, negative schizophrenic-like symptoms, or euphoria. Alfentanil is additive to ketamine in decreasing pain and increasing cognitive impairment. Physostigmine and 4-aminopyridine can antagonize some pharmacodynamic effects of ketamine. Buy Ketamine Crystal Powder for Sale Online Without Prescription.

Performance Effects of Ketamine Crystal Powder

Broad spectrum of cognitive impairments and mark dissociative effects. Increase distractibility and intensely visual or polysensual hallucinations. Impairment of immediate and delay recall, and verbal declarative memory. Memory impairment is associate with encoding or retrieval processes, and not account for by decrease attention. Impair language function, failure to form and use memory traces of task relevant information. Overall decrease awareness, increase reaction time, distort perceptions of space, non-responsiveness, and blurry vision. The S-(+) isomer impairs psychomotor function 3-5 times more than the R-(-) isomer. Buy Ketamine Crystal Powder for Sale Online Without Prescription.

Ketamine Crystal Powder Effects while Driving

The drug manufacturer suggests that patients should be caution that driving an automobile should not be undertaken for 24 hours or more following anesthesia. No driving studies have been perform.

DEC Category

Phencyclidine.

DEC Profile

Horizontal gaze nystagmus present; vertical gaze nystagmus present; lack of convergence present; pupil size normal; reaction to light normal; pulse rate elevate; blood pressure elevate; body temperature elevated. Other characteristic indicators may include rigid muscles, cyclic behavior, and lack of response to painful stimuli.

Driving Risks of Ketamine Crystal Powder

The use of ketamine is not conceivably compatible with the skills require for driving due to its moderate to severe psychomotor, cognitive, and residual effects. Buy Ketamine Crystal Powder for Sale Online Without Prescription.